α5-containing nicotinic acetylcholine receptors are important modulators of aggressive and dominant-like behaviors in rodents and humans
Fabrice De Chaumont, Romain Icick, Philip Gorwood, Sylvie Granon, Benoî Forget, Chloé Bouarab, Julia Mattioni, Cécile Saint-Cloment, Thomas Bourgeron, Uwe Maskos, Nicolas Ramoz, Morgane Besson · FENS Forum 2024
Aggression and substance use disorders (SUDs) show consistent associations, although their causal link remains to be understood. Human genetic studies have identified an association between a single nucleotide polymorphism (rs16969968) of the CHRNA5 gene encoding the α5 subunit of the nicotinic acetylcholine receptors (nAChRs) (α5SNP) and higher scores of nicotine dependence. We and others have shown that the α5SNP is associated with a loss of function of α5 containing nAChRs (α5*nAChRs) and strongly modulates addiction-like behaviors in response not only to nicotine but also to alcohol and co
ePoster · Neuroscience