Unravelling the role of prefrontal α7 nicotinic acetylcholine receptors in inhibitory control in physiological and pathological contexts: A behavioral investigation using touchscreen technology
Gabriela Medeiros, Chloé Bouarab, Pegah Azizi, Stéphanie Pons, Uwe Maskos, Morgane Besson · FENS Forum 2024
Dysfunctional α7 nicotinic acetylcholine receptors (α7*nAChRs) and their genetic regulation have been associated with several neuropsychiatric diseases, including schizophrenia and Alzheimer’s disease (AD). Preclinical studies revealed that α7*nAChR ligands can improve executive function, commonly impaired across neuropsychiatric disorders. Yet, a translational gap prevents these findings from resulting into clinically effective treatments. To tackle this translational gap, we combine approaches such as transgenic rats, viral vector-mediated local gene expression, touchscreen-based behavioral
ePoster · Neuroscience