Effects of dietary supplementation with deuterated polyunsaturated fatty acids in experimental traumatic brain injury
Ozgun Mavuk, Mikhail S. Shchepinov, Jordi L. Tremoleda, Adina T. Michael-Titus · FENS Forum 2024
Traumatic brain injury (TBI) can cause life-changing neurological deficits. There are currently no neuroprotective treatments in TBI. The high content of oxidation-sensitive polyunsaturated fatty acids (PUFAs) in the brain generates an environment vulnerable to TBI-related oxidative damage. We hypothesised that partial replacement of tissue PUFAs with deuterium - enriched PUFAs (D-PUFAs), could act as a brake against oxidation and improve outcome.A moderately severe TBI was induced using a controlled cortical impact (CCI) in adult male and female CD1 mice. Animals received a control or a D-PUF
ePoster · Neuroscience