Topic: Δ9‐Tetrahydrocannabinol (THC)

Neuronal Kv7 (KCNQ) voltage-gated potassium channels contribute to various neurophysiological functions (such as hearing, learning, and pain modulation), and, when mutated, cause distinct pathologies (such as hearing loss, epilepsy, and intellectual disability). Cannabidiol (CBD) is a pan-Kv7 modulator, Kv7.2/3 M-channel activator and EMA-approved antiepileptic. Yet, the potential therapeutic efficacy of similar phytocannabinoids on Kv7 channels remains to be studied. Here, we aim to investigate the pharmacology of cannabinoids structurally related to CBD, such as Δ9‑Tetrahydrocannabinol (THC)