A novel pro-neurogenic therapeutic approach for Alzheimer’s disease based on BRI2 proteolytic fragments
Sandra Rebelo, Gefei Chen, Vassal Mariana, Ruslana Savchuk, Zhao Hongjing, Nilsson Per, Tambaro Simone, Martins Filipa · FENS Forum 2024
Central nervous system (CNS) neurons have a limited capacity to spontaneously regenerate following injury and in neurodegenerative diseases, which calls for new pro-neurogenic strategies to counteract neurodegeneration. Therefore, understanding neuronal differentiation, function and plasticity by identifying key factors/modulators is a crucial demand to expand the knowledge on CNS ability to reorganize and adapt in res lesions response. BRI2 is a transmembrane protein, which undergoes proteolytic processing, resulting in generation of several secreted peptides whose function remains unknown. P
ePoster · Neuroscience