Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most common type of dementia worldwide. Pathological factors, such as Aβ deposition and glial cell activation, have been shown to be associated with changes of the glymphatic system, the drainage system of the brain parenchyma. However, the potential roles of astrocyte activity in the early stage of AD remain unclear. In this study, we aimed to investigate the changes in astrocyte activity and its pathological roles in the medial prefrontal cortex (mPFC) of 5xFAD mice at 4-5 months of age with two-photon microscopy, ch
ePoster · Neuroscience