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Topic: Aβ-pathology

ePoster
2 ePosters

In Neuroscience

Amyloid-β predicts oscillatory slowing and reduced functional connectivity over time in cognitively unimpaired adults

Elliz Scheijbeler, Willem De Haan, Emma Coomans, Anouk Den Braber, Jori Tomassen, Mara Ten Kate, Elles Konijnenberg, Lyduine E. Collij, Elsmarieke Van de Giessen, Frederik Barkhof, Pieter-Jelle Visser, Cornelis J. Stam, Alida A. Gouw · FENS Forum 2024

Amyloid-beta (Aβ)-induced changes in neuronal activity could yield valuable early markers of Alzheimer’s disease (AD). The neurophysiological manifestations associated with early Aβ-pathology in humans are however not well defined. This study investigated the relationship between Aβ-pathology and neurophysiological characteristics in 110 cognitively unimpaired individuals (65.9±5.7 years). All subjects underwent 18F-flutemetamol-PET imaging and resting-state magnetoencephalography (MEG) recording at baseline and 4-year follow-up. We tested associations between baseline Aβ-binding potentials (B

ePoster · Neuroscience

Optogenetic modulation of spatial hippocampal representations in a mouse model of Alzheimer’s disease

Manuel Mittag, Falko Fuhrmann, Eleonora Ambrad Giovannetti, Julia Steffen, Fabrizio Musacchio, Martin Fuhrmann · FENS Forum 2024

Disrupted neural oscillations and memory are common features of Alzheimer's disease (AD). Our previous studies have demonstrated the potential to restore theta oscillations by utilizing LFP-guided closed-loop optogenetic stimulation of local parvalbumin-positive (PV+) interneurons in the CA1 region of the hippocampus in APP/PS1dE9 mice. Furthermore, employing the same protocol, we successfully enhanced the performance of transgenic mice in a spatial memory tests. Based on these findings, our objective is to investigate the impact of PV+ stimulation on circuit function within the CA1 region. To

ePoster · Neuroscience