ePoster · Neuroscience
Exploring the potential role of atypical astrocytes in the early stages of Alzheimer’s disease in the APP NL-G-F mouse model
Panorea Tirja, Mary Sommer, Moritz Armbruster, Reyna Gariepy, Thomas Holtz, Miranda Good, Knarik Arkun, Chris Dulla · FENS Forum 2024
Atypical astrocytes (AtAs) are a distinct subset of non-reactive astrocytes in the brain characterized by dramatically diminished expression of excitatory amino acid transporters (GLAST, GLT1) and other astrocytic proteins. Our ongoing research on the development and progression of AtAs in naïve wild type (WT) mice has shown significant regional and age effects. We have also shown that brain tissue from confirmed Alzheimer’s Disease (AD) patients, as well as healthy controls, have areas of presumptive AtAs. This study aims to further explore the role of AtAs in AD pathology utilizing the APPNL