Microglial metabolism and immune function are pivotal factors in sexual dimorphism in Alzheimer’s disease
Eoin O'Neill, Marie-Victoire Guillot-Sestier, Ana Rubio, Virginia Mela, Marina A. Lynch · FENS Forum 2024
Age and sex are major risk factors in Alzheimer’s disease (AD) with a higher incidence of the disease in females. Chronic microglial activation and dysregulated neuro-inflammation are features of AD and may contribute to disease pathogenesis in a sexually dimorphic manner. We investigated sex differences in microglia in the APP/PS1 mouse model of Alzheimer’s disease and in post mortem brain tissue from patients with Alzheimer’s disease. Here we report elevated levels of activated, iron-laden and dystrophic microglia in the cortex and hippocampus of female APP/PS1 mice, and in post mortem tissu
ePoster · Neuroscience