Topic: A2A-CB2 receptor heteromer

Stroke is a leading cause of long-term disability worldwide with substantial economic costs. Hence, there is an urge for finding novel therapies to treat disability associated to stroke. This is the main reason research has focused on the discovery of key molecules involved in the functional prognosis of patients after stroke. Adenosine A2A and CB2 are receptors that have proven to be a new therapeutic target to consider in treatment of stroke. A common feature of these receptors in neurons is that their expression is upregulated in neuroinflammation process. On the one hand CB2R show a neurop