LTP at excitatory synapses onto inhibitory interneurons in the hippocampus depends on AMPA receptor surface mobility
Legeolas Velez, Aurélie Lampin-Saint-Amaux, Pablo Molle, Christelle Breillat, Daniel Choquet, Yann Humeau, Frédéric Lanore · FENS Forum 2024
Long-term synaptic plasticity (LTP) is the fundamental cellular mechanism which underlies long-term storage of information in neuronal circuits. Synaptic plasticity has mainly been studied on excitatory pyramidal neurons during memory formation. However, GABAergic interneurons are key players in orchestrating the dynamic of excitatory neuronal networks during this process. Thus, the excitatory synapses onto interneurons are central to this control as they constrain pyramidal-cells activity and set synaptic plasticity at excitatory-excitatory synapses. Nonetheless, how, when and where plasticit
ePoster · Neuroscience