ePoster · Neuroscience
K-Cl cotransporter KCC2 function is impaired in D2 receptor-expressing medium spiny neurons in a mouse model of Huntington's disease
Melissa Serranilla, Jessica C. Pressey, Melanie A. Woodin · FENS Forum 2024
Huntington’s disease (HD) is a progressive neurodegenerative disorder with no cure, characterized by significant neurodegeneration of striatal GABAergic medium spiny neurons (MSNs). Early stages of the disease are characterized by the loss of dopamine 2 receptor-expressing MSNs (D2 MSNs) followed by degeneration of dopamine 1 receptor-expressing MSNs (D1 MSNs), leading to aberrant basal ganglia signaling. While the early degeneration of D2 MSNs and impaired GABAergic transmission are well-documented, potassium chloride cotransporter 2 (KCC2), a key regulator of GABAergic signaling, has not bee