Anxiety in Parkinson’s disease: Brainstem neuromodulatory mechanisms
Alexia Lantheaume, Nina Schöneberg, Silvia Rodriguez Rozada, Michael Schellenberger, Dennis Doll, Konstantin Kobel, Kilian Katzenberger, Jérémy Signoret-Genest, Maria-Soledad Esposito, Philip Tovote · FENS Forum 2024
Among symptoms characterizing Parkinson’s disease (PD), freezing of gait (FoG) can become particularly disabling for patients. Anxiety levels have been linked to the severity of FoG, yet in this circumstance, levodopa treatment lacks effectiveness. A better understanding of the neural circuit mechanisms underlying FoG is required for a more targeted approach towards its treatment. To this end, we developed a viral vector (AAV2/9-CreON-A53T-αSyn) mouse model restricting synucleinopathy to local circuit elements, i.e. selected neuron subtypes within specific brain regions in vivo. We validated t
ePoster · Neuroscience