ePoster · Neuroscience
Selective expression of opsins in nociceptive neurons in the sciatic nerve of mice
Mary Ardren, Jerico Matarazzo, Elise Ajay, Sophie Payne, James Fallon, Rachael Richardson · FENS Forum 2024
Neuromodulation techniques offer drug-free management of chronic pain. However, electrical stimulation does not discriminate between sensory and motor fibres, nor between their functional subtypes, and can therefore result in off-target effects (e.g., motor activation). One way to alter nociceptive fibre activity alone is through the selective expression of light sensitive opsins within nociceptive fibres. Thus, light may be used to alter nociceptive activity whilst leaving neighbouring fibres unaffected. We selectively expressed either excitatory (channelrhodopsin; ChR2) or inhibitory (halorh