Developing double stranded RNAs to efficiently suppress expression of T-type Ca2+ channels for treating diabetic neuropathy
Dmytro Duzhyy, Alexandr Dovgan, Nikolai Kononenko, Andrew Dromaretsky, Nana Voitenko, Pavel Belan · FENS Forum 2024
Painful diabetic neuropathy (PDN), a chronic and often incurable syndrome, is one of the most common and unpleasant complications of diabetes. Effective clinical interventions for PDN are very limited and already developed approaches are characterized by lack of molecular or cellular target specificity and a short duration of therapeutic effects. Numerous investigations causally link upregulation of Cav3.2 T-type Ca2+ channels in peripheral nociceptive neurons to painful symptoms of PDN. Here we suggest an approach, based on implementation of virus-mediated cell-specific delivery of vectors ex
ePoster · Neuroscience