Viral encephalitis causes rapid transient depletion of neuronal progenitor cells and chronically alters neurogenesis in the adult mouse dentate gyrus
Alberto Pauletti, Polina Gurlo, Edna Weiß, Ana Beatriz DePaula-Silva, Karen Wilcox, Sonja Bröer · FENS Forum 2024
Infections of the CNS represent a significant predisposing factor for the manifestation of acute and chronic seizures. Epilepsy is associated with hippocampal sclerosis and neuronal degeneration; thus a regenerative approach could constitute a novel therapeutic option, involving the promotion of adult neurogenesis within the subgranular zone of the dentate gyrus (DG). Although experimental seizures induced by chemoconvulsants or electrical stimulation transiently enhance neurogenesis, the implications of encephalitis and virus-induced seizures remain inadequately elucidated. Accordingly, we em
ePoster · Neuroscience