LPS and pre-aggregated Abeta 1-42 lead to an increased neuroinflammatory response in cerebral organoids
Izaskun Itxaso, Tina Loeffler, Irene Schilcher, Magdalena Daurer, Stefanie Flunkert, Boris Philippe Chagnaud, Manuela Prokesch · FENS Forum 2024
Neuroinflammation represents a physiological response marked by immune cell activation and the release of inflammatory markers within the central nervous system. While it plays a pivotal protective role, when dysregulated it is also implicated in various neurological disorders such as Alzheimer disease. Brain organoids, self-organized three-dimensional (3D) aggregates derived from human induced pluripotent stem cells (iPSC), have emerged as a novel model to study brain development and disease. This study focuses on the development of a cerebral organoid model of neuroinflammation using pro and
ePoster · Neuroscience