Topic: abGCs

The capacities to learn and to store memories are two of the most important functions of the brain, but these abilities are inherently at odds with each other. On one hand, a neuronal network must be flexible enough to quickly store new information, but on the other it must be stable enough to prevent old memories from being constantly overwritten. Metaplasticity in which the timescale of synaptic modifications made by an individual neuron changes could resolve this flexibility-stability tradeoff. We propose that this strategy may be implemented in the olfactory bulb (OB). A striking, characte