Morphological alterations of striatal perineuronal nets in a rat model of parkinsonism and levodopa-induced dyskinesias
Nedime Tugce Bilbay, Banu Cahide Tel, Canan Cakir Aktas, Gul Yalcin Cakmakli, Bulent Elibol · FENS Forum 2024
Aims: L-DOPA-induced dyskinesias (LID) cause disability in Parkinson’s disease patients undergoing L-DOPA treatment. It is known that maladaptive plastic changes in both pre-and post-synaptic components of striatal network contribute to LID. However, the possible role of perineuronal nets (PNN), a member of the tetrapartite synaptic unit, is still elusive. We aimed to investigate alterations in PNN structure mainly encapsulating parvalbumin positive interneurons (PV-IN) in a rat model of LID.Methods: 6-OHDA toxin-injected hemiparkinsonian, sham-operated, and naïve Wistar male rats received eit
ePoster · Neuroscience