Dentate gyrus inhibitory microcircuit promotes network mechanisms underlying memory consolidation
Hannah Twarkowski,Victor Steininger,Min Jae Kim,Amar Sahay · COSYNE 2022
The hippocampal dentate gyrus (DG) to CA3 pathway plays a key role in encoding new experiences that are ultimately consolidated in the anterior cingulate cortex (ACC). Experience-dependent changes among excitatory neurons in the DG ‒ CA3 circuit have been intensely studied. However, DG cell axons innervate not only CA3 pyramidal neurons but also inhibitory, parvalbumin positive interneurons (PV IN) to provide strong feed-forward inhibition (FFI) onto CA3 pyramidal neurons. Following learning, FFI onto CA3 is temporarily increased which may be a key element for consolidation and long-term memor
Sat, Mar 19, 2022