Modulation of ageing mice microglia functions during neuroinflammation using synthetic cannabinoids
Akshay Kumar Vijaya, Greta Krisikaitytė, Simonas Kuras, Daiva Baltrukienė, Aurelijus Burokas · FENS Forum 2024
Aging is epitomized by a progressive increase in neuroinflammation which is associated with altered brain states, neuronal death and eventually neurodegeneration disease. Microglia are the resident macrophagic cells of the brain that play a crucial role in maintaining homeostasis and immune response especially during neuroinflammation. The endocannabinoid system (ECS) is a negative feedback signalling system that helps to maintain homeostasis. The ECS is able to modulate microglia activation states and functions through the endocannabinoid receptors CB1 and CB2. Although, the role of ECS and m
ePoster · Neuroscience