Topic: acetylcholine/glutamate co-transmission

Mood disorders such as depression or anxiety disorders are the most prevalent psychiatric diseases and represent the highest level of avoidable health-care cost in first world countries. Nonetheless, the biological foundation of these diseases is only poorly understood despite decades of research. Most clinically used antidepressants target the monoamine system and aim at either raising the levels of monoamines (serotonin, norepinephrine, dopamine) in the synaptic cleft through inhibition of reuptake or act on monoaminergic receptors. However, it takes several weeks until an antidepressant eff