Social memory and prepulse inhibition in APP/PS1 mice and the effect of chemogenetic manipulation of parvalbumin interneurons in the ventral hippocampus
Daniela Černotová, Karolína Hrůzová, Tereza Klausová, Aleš Stuchlík, Jan Svoboda · FENS Forum 2024
The ventral hippocampus (vHPC) is particularly sensitive to the pathology of Alzheimer’s disease (AD). Proper activity of the vHPC is mediated by parvalbumin (PV) interneurons, which constitute 25% of all inhibitory GABAergic cells. They play a crucial role in processing prepulse inhibition of the acoustic startle reflex (PPI) and social memory, which are managed by the vHPC. In this study, we first investigated the vHPC-related deficits in PPI and social novelty preference in 10-month-old APP/PS1 mice, a transgenic model of AD. We found a significant impairment in startle reduction in APP/PS1
ePoster · Neuroscience