Executive dysfunction and abnormal hippocampal-prefrontal intrinsic and synaptic excitability in the 3xTg mouse model for Alzheimer’s disease
Grace Cunliffe, Li Yang Tan, Sarah Luo, Jonathan Turner, Sangyong Jung, John Gigg · FENS Forum 2024
Executive dysfunction encompasses altered decision-making, excessive risk-taking behaviours and inefficient planning. Alongside memory loss, these cognitive deficits are amongst the most frequently reported symptoms of Alzheimer’s disease (AD). Normal executive function depends on connectivity between the ventral hippocampus (vHIP) and medial prefrontal cortex (mPFC), yet how abnormalities in this pathway lead to cognitive dysfunction in AD has yet to be elucidated. As the Iowa Gambling task effectively measures executive function in the clinic, the rodent 4-Choice Gambling task (4CGT) touchsc
ePoster · Neuroscience