Next-generation electrophysiology for functional characterization of human neural organoids
Laura D'ignazio, Elvira Guella, Zhuoliang Li, Anastasiia Oryshchuk, Praveena Manogaran, Marie Engelene Obien · FENS Forum 2024
Human induced pluripotent stem cell (hiPSC)-derived neural models have emerged as invaluable tools for studying neurological disorders, such as epilepsy, Alzheimer’s, and Parkinson’s disease.Real-time, label-free measurement of electrical activity in self-organizing in vitro cellular models provides critical insight into the complexity of their neuronal networks. High-density microelectrode arrays (HD-MEAs) enable non-invasive electrophysiological recordings from various electrogenic samples, including iPSC-derived neurons, retinal explants, brain slices, and neural organoids.In this study, we
ePoster · Neuroscience