Myelin loss disrupts neural synchrony directing skilled motor behavior in mouse primary motor cortex
Kimberly Gagnon, Gustavo Della Flora Nunes, Dailey Nettles, Ryan Williamson, Daniel Denman, Ethan Hughes, Cristin Welle · COSYNE 2023
Synchronization of neural activity is a fundamental component of information processing in the nervous system. Precise axonal conduction is required for correlated spiking activity between pairs of neurons at the millisecond timescale. Previous studies report that myelin loss results in deficient action potential propagation and a loss of population synchronization in the gamma band. Loss of myelination in demyelinating diseases like multiple sclerosis (MS) results in impaired motor function in patients with MS. However, a deeper understanding of how demyelination alters the timing, synchrony
Sun, Mar 12, 2023