Exploration of learning by dopamine D1 and D2 receptors by a spiking network model of the basal ganglia
Carlos Enrique Gutierrez,Jean Lienard,Benoît Girard,Hidetoshi Urakubo,Yuko Ishiwaka,Kenji Doya · COSYNE 2022
The basal ganglia (BG) play a crucial role in action-selection and reinforcement learning (RL), but how multiple nuclei, transmitters and receptors realize computations for reward-based learning is still unclear. We built a topologically organized spiking BG model. Striatal medium spiny neurons (MSN) were classified based on the expression of dopamine D1 and D2 receptors. We implemented spike-timing dependent plasticity and structural parameters: i) the asymmetry of connections between MSN’s; and ii) the overlap between direct and indirect pathways. In action-selection simulations, we assume
Fri, Mar 18, 2022