Topic: active mRNA transport

Understanding how neurons regulate their protein composition to refine their synaptic connections across millimetres of space can provide insights into the mechanism of plasticity. The discovery of local protein synthesis in subcellular compartments has illustrated how neuronal activity can meet the metabolic demands of synaptic plasticity locally. However, such research in axons remains experimentally challenging due to their long and complex branches. We thus developed an in silico approach to pinpoint the factors that markedly impact mRNA localization along the axon of a typical pyramidal n