Topic: Activin-A

Traumatic spinal cord injuries (SCIs) at the cervical level can lead to life-threatening breathing impairments. The extent of long-term functional improvement following SCI remains limited and it is therefore necessary to develop effective therapeutic interventions including transplantation of neural cells to replace lost cells and promote connectivity. While the focus has been on neurons, it is important to include immature astrocytes as they can promote neuroprotection, regeneration, and connectivity. We aim to leverage advanced cellular engineering techniques by co-transplanting human induc