Neuronal types in the mouse amygdala and their transcriptional states in fear memory
Hannah Hochgerner, Shelly Singh, Muhammad Tibi, Zhige Lin, Niv Skarbianskis, Inbal Admati, Osnat Ophir, Nuphar Reinhardt, Shai Netser, Shlomo Wagner, Amit Zeisel · FENS Forum 2024
The amygdala is a brain region primarily associated with emotional response. For example, fear learning and memory are known to activate neurons in the amygdala, which induce gene expression to strengthen the formation of stable engrams. Single-cell transcriptomics can provide insights into behavior-associated cell state changes. Here we present a detailed cell-type taxonomy of the adult mouse amygdala during fear learning and memory consolidation. We perform single-cell RNA sequencing on naïve and fear-conditioned mice, identify 130 neuronal cell types and validate their spatial distributions
ePoster · Neuroscience