Topic: activity sequences

Recurrent dynamics are thought to be central to computation in the cerebral cortex. Yet, how these dynamics differ across areas remains unknown. Here, we used two-photon microscopy to image Ca2+ activity from hundreds of neurons and while delivering brief, focal excitatory input with near-cellular- resolution optogenetics. Specifically, we compared how the primary visual (V1) and the secondary motor (M2) cortices distinctly sustain this input while mice ran spontaneously. Single-neuron responses to focal stimulation were much more prevalent in M2 than V1. Moreover, evoked network-level dynamic