Microglia modulate complex neuronal networks in acute brain slices despite their rapid, ATP-related phenotypic transformation
Peter Berki, Csaba Cserép, Zsuzsanna Környei, Balázs Pósfai, Eszter Szabadits, Andor Domonkos, Anna Kellermayer, Miklós Nyerges, Xiaofei Wei, Istvan Mody, Kunihiko Araki, Heinz Beck, Kaikai He, Ya Wang, Nikolett Lénárt, Zhaofa Wu, Miao Jing, Youlong Li, Attila I. Gulyás, Ádám Dénes · FENS Forum 2024
Acute brain slices represent a “workhorse” model for studying the central nervous system (CNS) from nanoscale events to complex circuits. While slice preparation inherently involves tissue damage, it is unclear how microglia, the main immune cells and damage sensors of the CNS react to this injury and shape neuronal activity ex vivo. To this end, we investigated microglial phenotypes and contribution to network organisation and functioning in acute brain slices. The comprehensive assesment of microglial states in acute brain slices demonstrated time-dependent microglial phenotype changes that
ePoster · Neuroscience