Topic: Acute extracellular recordings

Compared to mice, similar genetic tools have been traditionally very limited in rats, such that selective imaging or manipulation of circuits has been challenging. Developing blood-brain barrier (BBB) crossing and cell-type specific AAVs is an important research avenue as these viral vectors allow more precise control over transduction sparseness and coverage of larger target areas upon minimally invasive intravenous delivery (e.g. tail injections). One example of such an AAV is CAP-Mac, previously shown to be highly neuron-specific and to have high transduction efficiency in non-human primate