The emerging role of D4R in preventing morphine tolerance through the regulation of transcription factor expression in the dorsal horn
Marina Ponce, Belen Gago, Carolina Roza, Maria Angeles Real, Alicia Rivera · FENS Forum 2024
Morphine is one of the most effective analgesics used in the clinical management of pain. However, prolonged exposure to morphine results in a broad spectrum of adverse effects, including tolerance and addiction. Our prior findings indicate that the activation of the dopamine D4 receptor (D4R) prevents morphine addiction by modulating dopamine signalling in striatal regions involved in drug-habit formation and consolidation, without altering morphine-induced analgesia. Furthermore, it has been demonstrated that D4R in the terminals of primary nociceptors contributes to the anti-nociceptive eff
ePoster · Neuroscience