Topic: AD mouse model

The ability to learn new spatial memories is thought to depend on the plasticity of neural circuits in the hippocampus, whose progressive degradation in Alzheimer’s disease (AD) leads to severe cognitive impairments. While decades of in vitro studies indicate that astrocytes regulate various forms of neuronal synaptic plasticity, how the interplay between hippocampal astrocytes and neurons underlies spatial memory in vivo remains unknown, as does its potential link to AD's pathogenesis.To address these challenges, we developed a spatial memory task where mice, tracked with DeepLabCut automated