Autoantibody-induced synaptic and extrasynaptic dysfunction of LGI1 and Kv1 channels as a cause of LGI1 encephalitis
Josefine Sell, Vahid Rahmati, Andreas Ritzau-Jost, Felix Gsell, Sarosh Irani, Stefan Hallermann, Christian Geis · FENS Forum 2024
Autoantibodies against LGI1 cause limbic encephalitis with characteristic focal epileptic seizures and memory disorders. LGI1 is secreted by neurons and consists of two functional domains: a leucine-rich (LRR) and an epitempin (EPTP) region and forms complexes in synapses and axons via the receptors ADAM22/23 with Kv1 potassium channels and structural proteins such as PSD95 and glutamate receptors, whereby LGI1 can exert an influence on synaptic transmission and intrinsic excitability. To understand changes in neuronal function by LGI1 encephalitis, we used patients’ serum IgGs or monoclonal a
ePoster · Neuroscience