Topic: adaptation currents

Understanding the intricate functionality of the cerebral cortex requires integrating local circuit properties with global brain dynamics. Our study draws insights from biophysically detailed models of spiking neurons containing specific neural mechanisms, such as M-current and adaptation currents (Dalla Porta et al. Plos Comp. Bio., 2023). We incorporated these features in a mean-field model and, using human tractography data, we constructed a virtual whole-brain model consisting of 68 cortical nodes (Goldman et al. Front. Comput. Neurosci., 2023). To enhance realism, we introduced heterogene