Topic: ADCD

Chronic atopic dermatitis (AD) affects millions globally and has an alarming propensity to generate comorbid chronic depression. Currently, no effective therapies exist specifically for AD-generated comorbid depression (ADCD), likely due to unknown itch- and affect-processing brain mechanisms and inadequate preclinical models. Hence, there is a critical need for a suitable pre-clinical research model that can be used to study ADCD’s unique pathophysiology. In this investigation, we searched for preclinical models of ADCD by evaluating previously established house dust mite-induced (HDM model)