Topic: adducins

Neocortical development starts during embryogenesis with the main neural progenitor cells, classified as apical (APs) and basal progenitors (BPs). BPs are significantly enriched and highly proliferating in gyrencephalic species compared to lissencephalic, leading to neocortical expansion and increased cognitive abilities. BPs’ morphology is highly heterogeneous and correlates with proliferative ability, but the molecular mechanisms that regulate their fate are still unclear. Structural proteins have already been described as determinants of BPs’ morphology and fate; among them, the family of a