Investigating the glucose transporter 2 positive cells in the medial prefrontal cortex and their association with posttraumatic stress disorder in a mice model
Prabhat Kumar, Csilla Lea Fazekas, Pedro Correia, Dora Zelena · FENS Forum 2024
Posttraumatic stress disorder (PTSD), a psychopathological condition triggered by traumatic events, affects the brain's energy demand. The median prefrontal cortex (m-PFC) plays a crucial role in regulating the fear response. Moreover, it contains glucose-sensing glucose transporter 2 (GLUT2)-containing neurons. Therefore, we hypothesized that manipulation of these mPFC-GLUT2 cells could impact the behavioral outcome.An adeno-associated viral vector was used to deliver a stimulatory DREADD sequence into the mPFC of mice from both sexes. The infected cells were stimulated by clozapine-N-oxide r
ePoster · Neuroscience