The paradoxical role of adenosine A2A receptor in the control of synapse stabilization and elimination
Sabine Lévi, Solen Rimbert, Claire Montmasson, Chiara Fiorile, Marion Russeau, Emilie Faivre, David Blum · FENS Forum 2024
Adenosine acts as a fine regulator of synaptic plasticity in the adult brain. We showed a key role for the adenosine A2A receptor (A2AR) in the stabilization of nascent active GABAergic synapses during brain development (Gomez-Castro et al., Science 374 2021). Our data indicate that this regulation extends to glutamatergic synapses and involve neuroglial interactions. The suppression of neuronal A2AR with a shRNA approach in mixed neuron-glia cultures led to the loss of ~30% of glutamatergic synapses. Puzzlingly, activating A2AR in these cultures with a selective agonist (CGS21680) also led to
ePoster · Neuroscience