Olfactory dysfunction as a common denominator in multiple sclerosis and Parkinson’s disease – Evidence from animal models
Andjela Stekic, Milorad Dragic, Milica Zeljkovic Jovanovic, Nadezda Nedeljkovic · FENS Forum 2024
Olfactory dysfunction is an early symptom of neurodegenerative diseases, including Parkinson’s disease (PD) and multiple sclerosis (MS). Recent data showed that 30-40% MS patients and 90 % PD patients experience olfactory dysfunction. Studies have shown that adenosine signaling has a pivotal role in olfactory processing; thus, deciphering the changes in adenosine signaling may be crucial for understanding the disease pathogenesis. Aim of this study was to characterize olfactory dysfunction from the aspect of adenosine metabolism, focusing on ecto-5’ nucleotidase (CD73) in the olfactory bulb (O
ePoster · Neuroscience