Deciphering developmental-aging mechanisms in cell culture: Aberrant ADNP cytoplasmic-nuclear crosstalk and NAP (davunetide) protection
Maram Ganaiem, Nina D. Gildor, Shula Shazman, Gidon Karmon, Yanina Ivashko-Pachima, Illana Gozes · FENS Forum 2024
Background: Activity-dependent neuroprotective protein (ADNP) is crucial for chromatin/cytoskeletal functions. ADNP deregulation is linked to neurodevelopmental/neurodegenerative/psychiatric diseases. Mutations in ADNP cause the ADNP syndrome and parallel tauopathy in Alzheimer’. We showed aberrant nuclear-cytoplasmic distribution in ADNP-mutated neuronal-like cells, which was corrected by the ADNP-derived fragment, NAP (Cells, 2022). Here we asked what is the mechanism in which NAP corrects the aberrant distribution. Methods: CRISPR/Cas9 genome-editing established N1E-115 neuroblastoma cell l
ePoster · Neuroscience