Omega-3 fatty acids potentiate the endocannabinoid-dependent synaptic plasticity lost after adolescent binge drinking in male mouse dentate gyrus
Maitane Serrano, Garazi Ocerin, Miquel Saumell Esnaola, Amaia Mimenza, Itziar Bonilla Del Rio, Gontzal García Del Caño, Almudena Ramos Uriarte, Xabier Aretxabala, Leire Reguero, Inmaculada Gerrikagoitia, Nagore Puente, Pedro Grandes · FENS Forum 2024
Adolescence binge drinking impacts on cognition and behavior through the brain endocannabinoid system (ECS). Dietary long-chain polyunsaturated omega-3 (n-3) fatty acids increase hippocampal synaptic transmission and improve memory functions. Strikingly, alcohol (EtOH) decreases n-3 in the brain, having a negative effect on synaptic plasticity. Because adolescent binge drinking causes long-term impairment of the cannabinoid-dependent synaptic plasticity at the excitatory medial perforant path (MPP) synapses of the hippocampal dentate gyrus (Peñasco et al., 2020), we hypothesize that n-3 could
ePoster · Neuroscience