Cytokine production in dams with maternal depression and their adolescent offspring and effect of mirtazapine treatment
Stanislava Bukatova, Marek Lepacek, Mireia Viñas Noguera, Michal Dubovicky · FENS Forum 2024
The aim of the study was to determine the effect of chronic unpredictable stress (CUS) and maternal mirtazapine treatment on the pro-inflammatory cytokines IL-6 and TNF-α in the plasma of dams and their adolescent offspring (PP50) of both sexes.In the present study, mothers (n = 6-8/ group) and adolescent offspring (n = 6-8/ group) were divided into 4 groups: no stress+vehicle, no stress+mirtazapine, stress+vehicle, stress+mirtazapine. Dams in the stress group were exposed to CUS for a total of 3 weeks. Females from each group were then mated and treated from the 10th day of gestation to the 2
ePoster · Neuroscience