Topic: Adrenoceptors

Striatal dopamine (DA) is critical to the regulation of action selection and motivation. DA neurons have extensively branched axons which afford axonal regulation of DA release by diverse striatal neuromodulators including acetylcholine (ACh), GABA and adenosine, which regulate the amplitude and activity-sensitivity of DA release. Adrenoceptors are expressed throughout the striatum but their role, and that of norepinephrine (NE) as a potential striatal neuromodulator, is poorly understood. Given only a sparse norepinephrinergic input of the striatum but the dense innervation by DA, the endogen