Topic: adult mouse hippocampus

Microglia-synapse interactions have been examined in a variety of contexts, in vitro and in vivo, which revealed an important role for microglia in synaptic pruning and loss. Nevertheless, it remains to be determined whether and how microglia are involved in the process of synapse formation under physiologic conditions. We hypothesize that microglia serve as a link between pre- and post-synapse by sensing neurotransmitter release at highly active pre-synaptic sites and actively modulate the formation of new dendritic spines.To examine this relationship, we target microglia-synapse communicatio