Topic: adult neurons

Restoring the regenerative capacity of adult neurons after spinal cord injury has been an important challenge of the past decades. Unlike the peripheral branch of the nervous system, CNS axons fail to regenerate following injury. This inability has a two-fold origin, a neuron-extrinsic and -intrinsic one. The former has been well described in literature and is related to the inhibitory effect of the CNS environment on outgrowth of adult neurites. The latter has been attributed to the cellular makeup of adult neurons which is primed toward synaptic maturity and functionality, as opposed to rege