Topic: Adult stem cell niches

Background: Adult stem cell niches are specialized forms of extracellular matrix suitable for maintaining the development of newborn neurons. The process is regulated by internal and external factors, such as enriched environment (EE). The subgranular zone (SGZ) in the hippocampus is enriched with molecules such as tenascin C (TnC). It is a regulatory glycoprotein involved in the proliferation and migration of different cell types. The aim of this study was to examine how TnC affects the distribution of different biomolecules and the number of developing cells in the adult SGZ.Methods: To dire