Early microstructural alterations in Alzheimer’s disease: novel MRI biomarkers of Aß deposition and glial activation in APP/PS1 mouse model
Patricia Martínez Tazo, Antonio Cerdán Cerdá, Mohamed K. Selim, Santiago Canals, Jose Vicente Sanchez-Mut, Silvia De Santis · FENS Forum 2024
Alzheimer’s disease, a neurodegenerative disorder characterized by progressive cognitive decline and accumulation of amyloid-plaques and neurofibrillary-tangles[1], begins with microstructural damage 10-20 years before cognitive symptoms appear[2]; developing novel non-invasive approaches to characterize early Alzheimer-specific patterns has great potential to improve diagnosis. Neuroinflammation accompanies plaque formation and is a potential target for early detection[2]. Here, we aimed to test advanced MRI-based inflammation biomarkers to capture microstructural differences between APP/PS1
ePoster · Neuroscience